Next Article in Journal
Soy Protein-Based Infant Formulas with Supplemental Fructooligosaccharides: Gastrointestinal Tolerance and Hydration Status in Newborn Infants
Next Article in Special Issue
Can Skin Exposure to Sunlight Prevent Liver Inflammation?
Previous Article in Journal
Height, Zinc and Soil-Transmitted Helminth Infections in Schoolchildren: A Study in Cuba and Cambodia
Previous Article in Special Issue
Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
Article Menu

Export Article

Open AccessReview
Nutrients 2015, 7(4), 3011-3021; doi:10.3390/nu7043011

Vitamin D and 1,25(OH)2D Regulation of T cells

1
Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
2
Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
*
Author to whom correspondence should be addressed.
Received: 20 March 2015 / Revised: 14 April 2015 / Accepted: 16 April 2015 / Published: 22 April 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
View Full-Text   |   Download PDF [305 KB, uploaded 22 April 2015]   |  

Abstract

Vitamin D is a direct and indirect regulator of T cells. The mechanisms by which vitamin D directly regulates T cells are reviewed and new primary data on the effects of 1,25 dihydroxyvitamin D (1,25(OH)2D) on human invariant natural killer (iNK)T cells is presented. The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-γ, IL-17 and induction of IL-4. Experiments in mice demonstrate that the effectiveness of 1,25(OH)2D requires NKT cells, IL-10, the IL-10R and IL-4. Comparisons of mouse and human T cells show that 1,25(OH)2D inhibits IL-17 and IFN-γ, and induces T regulatory cells and IL-4. IL-4 was induced by 1,25(OH)2D in mouse and human iNKT cells. Activation for 72h was required for optimal expression of the vitamin D receptor (VDR) in human and mouse T and iNKT cells. In addition, T cells are potential autocrine sources of 1,25(OH)2D but again only 48–72h after activation. Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-γ, while inducing IL-4 and IL-10, would be beneficial. View Full-Text
Keywords: vitamin D; T cells; vitamin D receptor vitamin D; T cells; vitamin D receptor
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cantorna, M.T.; Snyder, L.; Lin, Y.-D.; Yang, L. Vitamin D and 1,25(OH)2D Regulation of T cells. Nutrients 2015, 7, 3011-3021.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top