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Nutrients 2015, 7(12), 10179-10188; doi:10.3390/nu7125526

The Effect of Lactobacillus plantarum 299v on the Incidence of Clostridium difficile Infection in High Risk Patients Treated with Antibiotics

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, School of Medicine in Katowice, Katowice 40-027, Poland
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Received: 10 June 2015 / Revised: 24 September 2015 / Accepted: 10 October 2015 / Published: 4 December 2015
(This article belongs to the Special Issue Microbiome and Human Health)
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Abstract

Background: Lactobacillus plantarum 299v (LP299v) has been used in order to reduce gastrointestinal symptoms during antibiotic exposure. However, it remains controversial whether or not probiotics are effective in the prevention of Clostridium difficile infections (CDI) among patients receiving antibiotics. The aim of this study was to analyze the CDI among patients receiving antibiotics and hospitalized in the period before and after starting routine use of LP299v as a prevention of this infection. Methods: Among 3533 patients hospitalized in the nephrology and transplantation ward during a two-year period, 23 patients with CDI were diagnosed and enrolled in this retrospective study. Since November 2013, prevention of CDI with oral use of LP299v was performed in all patients treated with antibiotics and who were at a high risk of developing CDI. The observation period was divided into two twelve-month intervals before and after initiation of the use of LP299v as a prophylactic against CDI. Results: A significant (p = 0.0001) reduction of the number of cases of CDI was found after routinely using LP299v (n = 2; 0.11% of all hospitalized patients) compared with the previous twelve-month period of observation (n = 21; 1.21% of all hospitalized patients). Conclusions: Routine use of LP299v during treatment with antibiotics may prevent C. difficile infection in the nephrology and transplantation ward. View Full-Text
Keywords: Lactobacillus plantarum 299v; Clostridium difficile; kidney transplantation; kidney and pancreas transplantation; liver transplantation; nephrology and transplantation ward Lactobacillus plantarum 299v; Clostridium difficile; kidney transplantation; kidney and pancreas transplantation; liver transplantation; nephrology and transplantation ward
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kujawa-Szewieczek, A.; Adamczak, M.; Kwiecień, K.; Dudzicz, S.; Gazda, M.; Więcek, A. The Effect of Lactobacillus plantarum 299v on the Incidence of Clostridium difficile Infection in High Risk Patients Treated with Antibiotics. Nutrients 2015, 7, 10179-10188.

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