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Nutrients 2015, 7(6), 4480-4497; doi:10.3390/nu7064480

Prebiotics Modulate the Effects of Antibiotics on Gut Microbial Diversity and Functioning in Vitro

1
Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot, Berkshire, SL5 7PY, UK
2
Food Microbial Sciences Unit, Department of Food and Nutritional Sciences, The University of Reading, Reading, Berkshire RG6 6AH, UK
3
Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, London W12 0HS, UK
*
Author to whom correspondence should be addressed.
Received: 22 April 2015 / Revised: 18 May 2015 / Accepted: 27 May 2015 / Published: 4 June 2015
(This article belongs to the Special Issue Microbiome and Human Health)
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Abstract

Intestinal bacteria carry out many fundamental roles, such as the fermentation of non-digestible dietary carbohydrates to produce short chain fatty acids (SCFAs), which can affect host energy levels and gut hormone regulation. Understanding how to manage this ecosystem to improve human health is an important but challenging goal. Antibiotics are the front line of defence against pathogens, but in turn they have adverse effects on indigenous microbial diversity and function. Here, we have investigated whether dietary supplementation—another method used to modulate gut composition and function—could be used to ameliorate the side effects of antibiotics. We perturbed gut bacterial communities with gentamicin and ampicillin in anaerobic batch cultures in vitro. Cultures were supplemented with either pectin (a non-fermentable fibre), inulin (a commonly used prebiotic that promotes the growth of beneficial bacteria) or neither. Although antibiotics often negated the beneficial effects of dietary supplementation, in some treatment combinations, notably ampicillin and inulin, dietary supplementation ameliorated the effects of antibiotics. There is therefore potential for using supplements to lessen the adverse effects of antibiotics. Further knowledge of such mechanisms could lead to better therapeutic manipulation of the human gut microbiota. View Full-Text
Keywords: gut microbiota; antibiotics; prebiotics; fibre gut microbiota; antibiotics; prebiotics; fibre
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Johnson, L.P.; Walton, G.E.; Psichas, A.; Frost, G.S.; Gibson, G.R.; Barraclough, T.G. Prebiotics Modulate the Effects of Antibiotics on Gut Microbial Diversity and Functioning in Vitro. Nutrients 2015, 7, 4480-4497.

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