Nutrients 2014, 6(4), 1752-1781; doi:10.3390/nu6041752
Review

Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

1email, 2email and 3,* email
Received: 25 October 2013; in revised form: 24 March 2014 / Accepted: 10 April 2014 / Published: 24 April 2014
(This article belongs to the Special Issue Vitamin C and Human Health)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer’s disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.
Keywords: ascorbic acid; vitamin C; brain; cognitive function; alzheimer’s disease; dementia; aging; elderly; endothelial function; blood-brain barrier; SVCT (sodium-dependent vitamin C transporter)
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MDPI and ACS Style

Harrison, F.E.; Bowman, G.L.; Polidori, M.C. Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline. Nutrients 2014, 6, 1752-1781.

AMA Style

Harrison FE, Bowman GL, Polidori MC. Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline. Nutrients. 2014; 6(4):1752-1781.

Chicago/Turabian Style

Harrison, Fiona E.; Bowman, Gene L.; Polidori, Maria C. 2014. "Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline." Nutrients 6, no. 4: 1752-1781.

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