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Nutrients 2014, 6(4), 1737-1751; doi:10.3390/nu6041737
Article

In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

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Received: 20 February 2014 / Revised: 9 April 2014 / Accepted: 21 April 2014 / Published: 24 April 2014
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Abstract

Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol extract (DR-EtOH) from D. rhizoma. Total phenolics and flavonoids were better extracted with 70% EtOH, and this extraction method also resulted in higher antioxidant activity and in vitro anti-osteoporosis properties in these extracts. In particular, the contents of phloroglucinol, protocatechuic acid ethyl ester, 2-amino-3,4-dimethyl-benzoic acid, 3-(3,5-dimethyl-pyrazol-1-yl)-benzoic acid, chlorogenic acid, syringic acid, trans-ferulic acid, (−)-epigallocatechin, epigallocatechin gallate, quercetin dehydrate, luteolin and emodin in DR-EtOH were higher than those in DR-DW. These results indicated that DR-EtOH could be a good source of natural herbs with anti-osteoporosis properties.
Keywords: Drynariae rhizoma; extraction solvent; phenolic compounds; antioxidant; anti-osteoporosis Drynariae rhizoma; extraction solvent; phenolic compounds; antioxidant; anti-osteoporosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kang, S.-N.; Lee, J.S.; Park, J.-H.; Cho, J.-H.; Park, J.-H.; Cho, K.-K.; Lee, O.-H.; Kim, I.-S. In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts. Nutrients 2014, 6, 1737-1751.

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