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Nutrients 2013, 5(8), 2860-2879; doi:10.3390/nu5082860
Review

Regulation of Vitamin C Homeostasis during Deficiency

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Received: 3 June 2013; in revised form: 15 July 2013 / Accepted: 18 July 2013 / Published: 25 July 2013
(This article belongs to the Special Issue Vitamin C and Human Health)
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Abstract: Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.
Keywords: vitamin C transport; sodium-dependent vitamin C transporters, SVCT1 and SVCT2; glucose transporters (GLUTs); regulation of transport vitamin C transport; sodium-dependent vitamin C transporters, SVCT1 and SVCT2; glucose transporters (GLUTs); regulation of transport
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lindblad, M.; Tveden-Nyborg, P.; Lykkesfeldt, J. Regulation of Vitamin C Homeostasis during Deficiency. Nutrients 2013, 5, 2860-2879.

AMA Style

Lindblad M, Tveden-Nyborg P, Lykkesfeldt J. Regulation of Vitamin C Homeostasis during Deficiency. Nutrients. 2013; 5(8):2860-2879.

Chicago/Turabian Style

Lindblad, Maiken; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. 2013. "Regulation of Vitamin C Homeostasis during Deficiency." Nutrients 5, no. 8: 2860-2879.


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