Next Article in Journal
Vitamin D Deficiency and the Lung: Disease Initiator or Disease Modifier?
Next Article in Special Issue
Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation
Previous Article in Journal
Iron Deprivation in Cancer––Potential Therapeutic Implications
Previous Article in Special Issue
Vitamin C in Cultured Human (HeLa) Cells: Lack of Effect on DNA Protection and Repair
Nutrients 2013, 5(8), 2860-2879; doi:10.3390/nu5082860
Review

Regulation of Vitamin C Homeostasis during Deficiency

,
 and
*
Received: 3 June 2013 / Revised: 15 July 2013 / Accepted: 18 July 2013 / Published: 25 July 2013
(This article belongs to the Special Issue Vitamin C and Human Health)
View Full-Text   |   Download PDF [756 KB, uploaded 25 July 2013]   |   Browse Figures

Abstract

Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.
Keywords: vitamin C transport; sodium-dependent vitamin C transporters, SVCT1 and SVCT2; glucose transporters (GLUTs); regulation of transport vitamin C transport; sodium-dependent vitamin C transporters, SVCT1 and SVCT2; glucose transporters (GLUTs); regulation of transport
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Lindblad, M.; Tveden-Nyborg, P.; Lykkesfeldt, J. Regulation of Vitamin C Homeostasis during Deficiency. Nutrients 2013, 5, 2860-2879.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert