Next Article in Journal
Developing and Implementing All-in-One Standard Paediatric Parenteral Nutrition
Next Article in Special Issue
Diminishing Risk for Age-Related Macular Degeneration with Nutrition: A Current View
Previous Article in Journal
Peculiarities of Enhancing Resistant Starch in Ruminants Using Chemical Methods: Opportunities and Challenges
Previous Article in Special Issue
Macular Pigment and Its Contribution to Vision
Nutrients 2013, 5(6), 1989-2005; doi:10.3390/nu5061989
Case Report

Observation of Human Retinal Remodeling in Octogenarians with a Resveratrol Based Nutritional Supplement

* ,
,
,
 and
Received: 8 March 2013; in revised form: 10 May 2013 / Accepted: 13 May 2013 / Published: 4 June 2013
(This article belongs to the Special Issue Nutrition and the Eye)
View Full-Text   |   Download PDF [1383 KB, uploaded 4 June 2013]   |   Browse Figures
Abstract: Purpose: Rare spontaneous remissions from age-related macular degeneration (AMD) suggest the human retina has large regenerative capacity, even in advanced age. We present examples of robust improvement of retinal structure and function using an OTC oral resveratrol (RV) based nutritional supplement called Longevinex® or L/RV (circa 2004, Resveratrol Partners, LLC, Las Vegas, NV, USA). RV, a polyphenolic phytoalexin caloric-restriction mimic, induces hormesis at low doses with widespread beneficial effects on systemic health. RV alone inhibits neovascularization in the murine retina. Thus far, published evidence includes L/RV mitigation of experimentally induced murine cardiovascular reperfusion injury, amelioration of human atherosclerosis serum biomarkers in a human Japanese randomized placebo controlled trial, modulation of micro RNA 20b and 539 that control hypoxia-inducing-factor (HIF-1) and vascular endothelial growth factor (VEGF) genes in the murine heart (RV inhibited micro RNA20b 189-fold, L/RV 1366-fold). Little is known about the effects of L/RV on human ocular pathology. Methods: Absent FDA IRB approval, but with permission from our Chief of Staff and medical center IRB, L/RV is reserved for AMD patients, on a case-by-case compassionate care basis. Patients include those who progress on AREDS II type supplements, refuse intra-vitreal anti-VEGF injections or fail to respond to Lucentis®, Avastin® or Eylea®. Patients are clinically followed traditionally as well as with multi-spectral retinal imaging, visual acuity, contrast sensitivity, cone glare recovery and macular visual fields. Three cases are presented. Results: Observed dramatic short-term anti-VEGF type effect including anatomic restoration of retinal structure with a suggestion of improvement in choroidal blood flow by near IR multispectral imaging. The visual function improvement mirrors the effect seen anatomically. The effect is bilateral with the added benefit of better RPE function. Effects have lasted for one year or longer when taken daily, at which point one patient required initiation of anti-VEGF agents. Unanticipated systemic benefits were observed. Conclusions: Preliminary observations support previous publications in animals and humans. Restoration of structure and visual function in octogenarians with daily oral consumption of L/RV is documented. Applications include failure on AREDS II supplements, refusing or failing conventional anti-VEGF therapy, adjunct therapy to improve RPE function, and compassionate use in medically underserved or economically depressed third-world countries.
Keywords: macular degeneration; gene expression; epigenetics; RPE (retinal pigment epithelium) function; VEGF; pharmacogenomics macular degeneration; gene expression; epigenetics; RPE (retinal pigment epithelium) function; VEGF; pharmacogenomics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Richer, S.; Stiles, W.; Ulanski, L.; Carroll, D.; Podella, C. Observation of Human Retinal Remodeling in Octogenarians with a Resveratrol Based Nutritional Supplement. Nutrients 2013, 5, 1989-2005.

AMA Style

Richer S, Stiles W, Ulanski L, Carroll D, Podella C. Observation of Human Retinal Remodeling in Octogenarians with a Resveratrol Based Nutritional Supplement. Nutrients. 2013; 5(6):1989-2005.

Chicago/Turabian Style

Richer, Stuart; Stiles, William; Ulanski, Lawrence; Carroll, Donn; Podella, Carla. 2013. "Observation of Human Retinal Remodeling in Octogenarians with a Resveratrol Based Nutritional Supplement." Nutrients 5, no. 6: 1989-2005.


Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert