Nutrients 2013, 5(2), 543-551; doi:10.3390/nu5020543
Brief Report

Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial

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Received: 24 December 2012; in revised form: 30 January 2013 / Accepted: 4 February 2013 / Published: 15 February 2013
(This article belongs to the Special Issue Nutrition and the Eye)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We studied the macular pigment ocular density (MPOD) in patients with early age macular degeneration (AMD) before and 1 year after nutritional supplementation with lutein and docosahexaenoic acid (DHA). Forty-four patients with AMD were randomly divided into two groups that received placebo (n = 21) or a nutritional supplement (n = 23, 12 mg of lutein and 280 mg of DHA daily). Heterochromatic flicker photometry was used to determine the MPOD. At baseline, the MPOD in AMD patients with placebo was 0.286 ± 0.017 meanwhile in AMD patients with supplementation it was 0.291 ± 0.016. One year later, the mean MPOD had increased by 0.059 in the placebo group and by 0.162 in patients receiving lutein and DHA. This difference between groups was significant (p < 0.05). Lutein and DHA supplementation is effective in increasing the MPOD and may aid in prevention of age related macular degeneration.
Keywords: lutein; docosahexaenoic acid; age-related macular degeneration; macular pigment density
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MDPI and ACS Style

García-Layana, A.; Recalde, S.; Alamán, A.S.; Robredo, P.F. Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial. Nutrients 2013, 5, 543-551.

AMA Style

García-Layana A, Recalde S, Alamán AS, Robredo PF. Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial. Nutrients. 2013; 5(2):543-551.

Chicago/Turabian Style

García-Layana, Alfredo; Recalde, Sergio; Alamán, Angel S.; Robredo, Patricia F. 2013. "Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial." Nutrients 5, no. 2: 543-551.


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