Nutrients 2013, 5(2), 543-551; doi:10.3390/nu5020543
Brief Report

Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial

Ophthalmology Department, Clinica Universidad de Navarra, C/ Pio XII 36, 31080, Pamplona, Spain
* Author to whom correspondence should be addressed.
Received: 24 December 2012; in revised form: 30 January 2013 / Accepted: 4 February 2013 / Published: 15 February 2013
(This article belongs to the Special Issue Nutrition and the Eye)
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Abstract: We studied the macular pigment ocular density (MPOD) in patients with early age macular degeneration (AMD) before and 1 year after nutritional supplementation with lutein and docosahexaenoic acid (DHA). Forty-four patients with AMD were randomly divided into two groups that received placebo (n = 21) or a nutritional supplement (n = 23, 12 mg of lutein and 280 mg of DHA daily). Heterochromatic flicker photometry was used to determine the MPOD. At baseline, the MPOD in AMD patients with placebo was 0.286 ± 0.017 meanwhile in AMD patients with supplementation it was 0.291 ± 0.016. One year later, the mean MPOD had increased by 0.059 in the placebo group and by 0.162 in patients receiving lutein and DHA. This difference between groups was significant (p < 0.05). Lutein and DHA supplementation is effective in increasing the MPOD and may aid in prevention of age related macular degeneration.
Keywords: lutein; docosahexaenoic acid; age-related macular degeneration; macular pigment density

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MDPI and ACS Style

García-Layana, A.; Recalde, S.; Alamán, A.S.; Robredo, P.F. Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial. Nutrients 2013, 5, 543-551.

AMA Style

García-Layana A, Recalde S, Alamán AS, Robredo PF. Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial. Nutrients. 2013; 5(2):543-551.

Chicago/Turabian Style

García-Layana, Alfredo; Recalde, Sergio; Alamán, Angel S.; Robredo, Patricia F. 2013. "Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial." Nutrients 5, no. 2: 543-551.

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