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Nutrients 2013, 5(11), 4653-4664; doi:10.3390/nu5114653
Article

Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study

1,* , 1
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, 2
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, 4
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1 Department of Pediatrics, Università Politecnica delle Marche, 60121 Ancona, Italy 2 Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy 3 Department of Pediatrics, "Sapienza" University of Rome, 00161 Roma, Italy 4 Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milano, Italy 5 Department of Pediatrics, S. Maria dell'Olmo Hospital Cava de' Tirreni, 84013 Salerno, Italy 6 Pediatric Gastroenterology Unit, "G. Di Cristina" Children Hospital, 90134 Palermo, Italy 7 Heinz Italia S.p.A, 04100 Latina, Italy 8 Department of Epidemiology, Biostatistics and Medical Information Technology, Università Politecnica delle Marche, 60121 Ancona, Italy 9 Department of Pediatrics, Università di Catania, 95123, Catania, Italy
* Author to whom correspondence should be addressed.
Received: 30 September 2013 / Revised: 13 November 2013 / Accepted: 13 November 2013 / Published: 20 November 2013
(This article belongs to the Special Issue Nutrition and Celiac Disease)
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Abstract

A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet “A”, 3 months of standard GFD, 6 months of diet “B”), or B-A treatment (6 months of diet “B”, 3 months of standard GFD, 6 months of diet “A”). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.
Keywords: oats; celiac disease; gluten-free diet; intestinal permeability; gastrointestinal symptoms oats; celiac disease; gluten-free diet; intestinal permeability; gastrointestinal symptoms
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gatti, S.; Caporelli, N.; Galeazzi, T.; Francavilla, R.; Barbato, M.; Roggero, P.; Malamisura, B.; Iacono, G.; Budelli, A.; Gesuita, R.; Catassi, C.; Lionetti, E. Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study. Nutrients 2013, 5, 4653-4664.

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