Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Nutrients 2013, 5(11), 4399-4413; doi:10.3390/nu5114399
Review

The Influence of Vitamin A Supplementation on Iron Status

1
, 2
, 3
, 4
 and 4,*
Received: 16 September 2013; in revised form: 10 October 2013 / Accepted: 30 October 2013 / Published: 7 November 2013
(This article belongs to the Special Issue Vitamin A and Carotenoids)
View Full-Text   |   Download PDF [228 KB, uploaded 7 November 2013]   |   Browse Figure
Abstract: Vitamin A (VA) and iron deficiencies are important nutritional problems, affecting particularly preschool children, as well as pregnant and lactating women. A PubMed (National Library of Medicine, National Institutes of Health, Bethesda, MD, USA) literature review was carried out to search for clinical trials published from 1992 to 2013 that assessed the influence of vitamin A supplementation on iron status. Simultaneous use of iron and vitamin A supplements seemed to be more effective to prevent iron deficiency anemia than the use of these micronutrients alone. Some studies did not include a placebo group and only a few of them assessed vitamin A status of the individuals at baseline. Moreover, the studies did not consider any inflammatory marker and a reasonable number of iron parameters. Another important limitation was the lack of assessment of hemoglobin variants, especially in regions with a high prevalence of anemia. Assessment of hemoglobin variants, inflammatory markers and anemia of chronic inflammation would be important to the studies investigated. Studies involving different populations are necessary to elucidate the interaction between the two micronutrients, especially regarding iron absorption and modulation of erythropoiesis.
Keywords: vitamin A; iron; anemia; iron deficiency anemia; micronutrients vitamin A; iron; anemia; iron deficiency anemia; micronutrients
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Michelazzo, F.B.; Oliveira, J.M.; Stefanello, J.; Luzia, L.A.; Rondó, P.H.C. The Influence of Vitamin A Supplementation on Iron Status. Nutrients 2013, 5, 4399-4413.

AMA Style

Michelazzo FB, Oliveira JM, Stefanello J, Luzia LA, Rondó PHC. The Influence of Vitamin A Supplementation on Iron Status. Nutrients. 2013; 5(11):4399-4413.

Chicago/Turabian Style

Michelazzo, Fernanda B.; Oliveira, Julicristie M.; Stefanello, Juliana; Luzia, Liania A.; Rondó, Patricia H.C. 2013. "The Influence of Vitamin A Supplementation on Iron Status." Nutrients 5, no. 11: 4399-4413.



Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert