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Nutrients 2013, 5(11), 4390-4398; doi:10.3390/nu5114390
Review

Vitamin K Status in Chronic Kidney Disease

1
, 1 and 2,*
1 Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3V6, Canada 2 Department of Medicine, Queen's University, Kingston, ON K7L 3V6, Canada
* Author to whom correspondence should be addressed.
Received: 11 July 2013 / Revised: 17 October 2013 / Accepted: 31 October 2013 / Published: 7 November 2013
(This article belongs to the Special Issue Vitamin K Nutrition and Metabolism)
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Abstract

The purpose of this review is to summarize the research to date on vitamin K status in chronic kidney disease (CKD). This review includes a summary of the data available on vitamin K status in patients across the spectrum of CKD as well as the link between vitamin K deficiency in CKD and bone dynamics, including mineralization and demineralization, as well as ectopic mineralization. It also describes two current clinical trials that are underway evaluating vitamin K treatment in CKD patients. These data may inform future clinical practice in this population.
Keywords: vitamin K; chronic kidney disease; renal insufficiency; vitamin K-dependent proteins vitamin K; chronic kidney disease; renal insufficiency; vitamin K-dependent proteins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

McCabe, K.M.; Adams, M.A.; Holden, R.M. Vitamin K Status in Chronic Kidney Disease. Nutrients 2013, 5, 4390-4398.

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