Next Article in Journal
Anorexia of Aging: A Modifiable Risk Factor for Frailty
Next Article in Special Issue
Vitamin E Isoforms as Modulators of Lung Inflammation
Previous Article in Journal
Nutritional Management of Insulin Resistance in Nonalcoholic Fatty Liver Disease (NAFLD)
Previous Article in Special Issue
Childhood Overweight/Obesity and Pediatric Asthma: The Role of Parental Perception of Child Weight Status
Nutrients 2013, 5(10), 4115-4125; doi:10.3390/nu5104115

Adiponectin: An Attractive Marker for Metabolic Disorders in Chronic Obstructive Pulmonary Disease (COPD)

1,†,* , 2,†
1 Department of Medicine and Health Sciences, University of Molise, Via Giovanni Paolo II, Loc. Tappino, Campobasso 86100, Italy 2 Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Via Leonardo Bianchi, Monaldi Hospital, Naples 80131, Italy 3 CEINGE Biotecnologie Avanzate Scarl, Via Gaetano Salvatore 486, Naples 80145, Italy 4 IRCCS–Fondazione SDN, Naples 80131, Italy 5 Department of Respiratory Medicine, AO Monaldi, University of Naples Federico II, Via Leonardo Bianchi, Monaldi Hospital, Naples 80131, Italy 6 Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, Caserta 81100, Italy These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 3 June 2013 / Revised: 18 September 2013 / Accepted: 23 September 2013 / Published: 14 October 2013
(This article belongs to the Special Issue Nutrition and Respiratory Disease)
View Full-Text   |   Download PDF [209 KB, uploaded 14 October 2013]


Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease which may be complicated by development of co-morbidities including metabolic disorders. Metabolic disorders commonly associated with this disease contribute to lung function impairment and mortality. Systemic inflammation appears to be a major factor linking COPD to metabolic alterations. Adipose tissue seems to interfere with systemic inflammation in COPD patients by producing a large number of proteins, known as “adipokines”, involved in various processes such as metabolism, immunity and inflammation. There is evidence that adiponectin is an important modulator of inflammatory processes implicated in airway pathophysiology. Increased serum levels of adiponectin and expression of its receptors on lung tissues of COPD patients have recently highlighted the importance of the adiponectin pathway in this disease. Further, in vitro studies have demonstrated an anti-inflammatory activity for this adipokine at the level of lung epithelium. This review focuses on mechanisms by which adiponectin is implicated in linking COPD with metabolic disorders.
Keywords: COPD; adiponectin; metabolic disorders; adipose tissue COPD; adiponectin; metabolic disorders; adipose tissue
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Bianco, A.; Mazzarella, G.; Turchiarelli, V.; Nigro, E.; Corbi, G.; Scudiero, O.; Sofia, M.; Daniele, A. Adiponectin: An Attractive Marker for Metabolic Disorders in Chronic Obstructive Pulmonary Disease (COPD). Nutrients 2013, 5, 4115-4125.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert