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Nutrients 2013, 5(11), 4347-4363; doi:10.3390/nu5114347
Review

Vitamin E Isoforms as Modulators of Lung Inflammation

,
 and *
Allergy-Immunology Division, Feinberg School of Medicine, Northwestern University, McGaw-M304, 240 E. Huron, Chicago, IL 60611, USA
* Author to whom correspondence should be addressed.
Received: 11 July 2013 / Revised: 12 October 2013 / Accepted: 18 October 2013 / Published: 31 October 2013
(This article belongs to the Special Issue Nutrition and Respiratory Disease)
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Abstract

Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.
Keywords: tocopherols; lung disease; endothelial tocopherols; lung disease; endothelial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Abdala-Valencia, H.; Berdnikovs, S.; Cook-Mills, J.M. Vitamin E Isoforms as Modulators of Lung Inflammation. Nutrients 2013, 5, 4347-4363.

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