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Vitamin E Isoforms as Modulators of Lung Inflammation
Allergy-Immunology Division, Feinberg School of Medicine, Northwestern University, McGaw-M304, 240 E. Huron, Chicago, IL 60611, USA
* Author to whom correspondence should be addressed.
Received: 11 July 2013; in revised form: 12 October 2013 / Accepted: 18 October 2013 / Published: 31 October 2013
Abstract: Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.
Keywords: tocopherols; lung disease; endothelial
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Abdala-Valencia, H.; Berdnikovs, S.; Cook-Mills, J.M. Vitamin E Isoforms as Modulators of Lung Inflammation. Nutrients 2013, 5, 4347-4363.
Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E Isoforms as Modulators of Lung Inflammation. Nutrients. 2013; 5(11):4347-4363.
Abdala-Valencia, Hiam; Berdnikovs, Sergejs; Cook-Mills, Joan M. 2013. "Vitamin E Isoforms as Modulators of Lung Inflammation." Nutrients 5, no. 11: 4347-4363.