Next Article in Journal
Food Labels Use Is Associated with Higher Adherence to Mediterranean Diet: Results from the Moli-Sani Study
Next Article in Special Issue
Nutrition and Respiratory Health—Feature Review
Previous Article in Journal
The Need for Evidence Based Nutritional Guidelines for Pediatric Acute Lymphoblastic Leukemia Patients: Acute and Long-Term Following Treatment
Previous Article in Special Issue
Adiponectin: An Attractive Marker for Metabolic Disorders in Chronic Obstructive Pulmonary Disease (COPD)
Nutrients 2013, 5(11), 4347-4363; doi:10.3390/nu5114347
Review

Vitamin E Isoforms as Modulators of Lung Inflammation

,
 and
*
Allergy-Immunology Division, Feinberg School of Medicine, Northwestern University, McGaw-M304, 240 E. Huron, Chicago, IL 60611, USA
* Author to whom correspondence should be addressed.
Received: 11 July 2013 / Revised: 12 October 2013 / Accepted: 18 October 2013 / Published: 31 October 2013
(This article belongs to the Special Issue Nutrition and Respiratory Disease)
View Full-Text   |   Download PDF [315 KB, uploaded 31 October 2013]   |  

Abstract

Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.
Keywords: tocopherols; lung disease; endothelial tocopherols; lung disease; endothelial
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Abdala-Valencia, H.; Berdnikovs, S.; Cook-Mills, J.M. Vitamin E Isoforms as Modulators of Lung Inflammation. Nutrients 2013, 5, 4347-4363.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert