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• Cao, JJ.
• Combs, GF.
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• Cao, JJ.
• Combs, GF.
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• Zeng, H
• Cao, JJ.
• Combs, GF.

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Nutrients 2013, 5(1), 97-110; doi:10.3390/nu5010097

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Selenium in Bone Health: Roles in Antioxidant Protection and Cell Proliferation

Huawei Zeng* , Jay J. Cao and Gerald F. Combs Jr.

Grand Forks Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, ND 58202, USA

* Author to whom correspondence should be addressed.

Received: 28 November 2012; in revised form: 17 December 2012 / Accepted: 3 January 2013 / Published: 10 January 2013

(This article belongs to the Special Issue Dietary Selenium and Health)

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Abstract: Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Elucidation of the mechanisms by which Se supports these cellular processes can lead to a better understanding of the role of this nutrient in normal bone metabolism. This article reviews the current knowledge concerning the molecular functions of Se relevant to bone health.

Keywords: antioxidant; bone health; cell proliferation

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