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Nutrients 2012, 4(10), 1490-1503; doi:10.3390/nu4101490

Risk of Parenteral Nutrition in Neonates—An Overview

1,* , 2
1 Infection Control Programme, University of Geneva Hospitals, rue Gabrielle Perret-Gentil 4, 1211 Genève 14, Switzerland 2 Neonatology Unit, Department of Pediatrics, Stadtspital Triemli, Birmensdorferstrasse 497, 8055 Zürich, Switzerland 3 Division of Infection Control and Hospital Epidemiology, Department of Environmental Health Sciences, University Medical Center Freiburg, Breisacher Str. 115b, 79106 Freiburg, Germany
* Author to whom correspondence should be addressed.
Received: 15 July 2012 / Revised: 29 August 2012 / Accepted: 25 September 2012 / Published: 16 October 2012
(This article belongs to the Special Issue Parenteral Nutrition)
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Healthcare-associated infections (HAI) in preterm infants are a challenge to the care of these fragile patients. HAI-incidence rates range from 6 to 27 infections per 1000 patient-days. Most nosocomial infections are bloodstream infections and of these, the majority is associated with the use of central venous catheters. Many studies identified parenteral nutrition as an independent risk factor for HAI, catheter-associated bloodstream infection, and clinical sepsis. This fact and various published outbreaks due to contaminated parenteral nutrition preparations highlight the importance of appropriate standards in the preparation and handling of intravenous solutions and parenteral nutrition. Ready-to-use parenteral nutrition formulations may provide additional safety in this context. However, there is concern that such formulations may result in overfeeding and necrotizing enterocolitis. Given the risk for catheter-associated infection, handling with parenteral nutrition should be minimized and the duration shortened. Further research is required about this topic.
Keywords: newborn; preterm; neonate; healthcare-associated infection; parenteral nutrition; bloodstream infection; intravenous catheter; compounded formula; ready-to-use newborn; preterm; neonate; healthcare-associated infection; parenteral nutrition; bloodstream infection; intravenous catheter; compounded formula; ready-to-use
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zingg, W.; Tomaske, M.; Martin, M. Risk of Parenteral Nutrition in Neonates—An Overview. Nutrients 2012, 4, 1490-1503.

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