Nutrients 2012, 4(1), 52-67; doi:10.3390/nu4010052
Review

Focus on Vitamin D, Inflammation and Type 2 Diabetes

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Received: 2 December 2011; in revised form: 29 December 2011 / Accepted: 9 January 2012 / Published: 20 January 2012
(This article belongs to the Special Issue Vitamin D)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes.
Keywords: vitamin D; inflammation; diabetes
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MDPI and ACS Style

Chagas, C.E.A.; Borges, M.C.; Martini, L.A.; Rogero, M.M. Focus on Vitamin D, Inflammation and Type 2 Diabetes. Nutrients 2012, 4, 52-67.

AMA Style

Chagas CEA, Borges MC, Martini LA, Rogero MM. Focus on Vitamin D, Inflammation and Type 2 Diabetes. Nutrients. 2012; 4(1):52-67.

Chicago/Turabian Style

Chagas, Carlos Eduardo Andrade; Borges, Maria Carolina; Martini, Lígia Araújo; Rogero, Marcelo Macedo. 2012. "Focus on Vitamin D, Inflammation and Type 2 Diabetes." Nutrients 4, no. 1: 52-67.

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