Next Article in Journal / Special Issue
Evidence of Associations Between Feto-Maternal Vitamin D Status, Cord Parathyroid Hormone and Bone-Specific Alkaline Phosphatase, and Newborn Whole Body Bone Mineral Content
Previous Article in Journal / Special Issue
Theobald Palm and His Remarkable Observation: How the Sunshine Vitamin Came to Be Recognized
Nutrients 2012, 4(1), 52-67; doi:10.3390/nu4010052
Review

Focus on Vitamin D, Inflammation and Type 2 Diabetes

1
,
2
,
2
 and
2,*
1 Center for Nutrition Practice and Research, Department of Education, Institute of Biosciences, São Paulo State University, Botucatu, SP 18618-970, Brazil 2 Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 01246-904, Brazil
* Author to whom correspondence should be addressed.
Received: 2 December 2011 / Revised: 29 December 2011 / Accepted: 9 January 2012 / Published: 20 January 2012
(This article belongs to the Special Issue Vitamin D)
View Full-Text   |   Download PDF [352 KB, uploaded 20 January 2012]   |   Browse Figures
SciFeed

Abstract

The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes.
Keywords: vitamin D; inflammation; diabetes vitamin D; inflammation; diabetes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Chagas, C.E.A.; Borges, M.C.; Martini, L.A.; Rogero, M.M. Focus on Vitamin D, Inflammation and Type 2 Diabetes. Nutrients 2012, 4, 52-67.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert