Nutrients 2012, 4(1), 29-41; doi:10.3390/nu4010029
Article

Combined Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a Cross-Sectional Study in a Community Setting

Martin M. Root 1,* email, Megan C. McGinn 2 email, David C. Nieman 3 email, Dru A. Henson 4 email, Serena A. Heinz 5 email, R. Andrew Shanely 3 email, Amy M. Knab 3 email and Fuxia Jin 6 email
1 Department of Nutrition and Health Care Management, Appalachian State University, ASU Box 32168, Boone, NC 28608, USA 2 Silver Bluff Village, 100 Silver Bluff Drive, Canton, NC 28716, USA 3 Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA 4 Department of Biology, Appalachian State University, Boone, NC 28608, USA 5 Carver College of Medicine, University of Iowa, 2206 Medical Education & Research Facility, Iowa City, IA 52242, USA 6 Dole Nutrition Research Laboratory, 600 Laureate Way, Kannapolis, NC 28081, USA
* Author to whom correspondence should be addressed.
Received: 1 December 2011; in revised form: 30 December 2011 / Accepted: 31 December 2011 / Published: 4 January 2012
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Abstract: Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined self-reported fruit and vegetable (F&V) intake in a community setting was associated with improved multiple markers of inflammatory and oxidant status. A community group (N = 1000, age 18–85 years, 61% female) gave two fasted blood samples separated by 12 weeks. Blood inflammatory biomarkers included total leukocytes (WBC), plasma C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1, and granulocyte colony stimulating factor. Measured oxidant status markers were ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC) and plasma F2-isoprostanes. The relation of markers across categories of F&V intake was examined. In analyses controlling for other important dietary and lifestyle factors, IL-6 and TNF-α were significantly lower across categories of increasing F&V intakes (p < 0.008). FRAP and ORAC were significantly higher (p < 0.0001 and p = 0.047 respectively) while F2-isoprostanes was significantly lower (p < 0.0001) across F&V categories. In a community study, several markers of both inflammation and oxidant status were associated in a putatively salutary direction by higher intake of combined F&V, supporting current guidelines suggesting increased F&V consumption for the prevention of chronic diseases.
Keywords: fruits; vegetables; inflammation; oxidant status

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Cite This Article

MDPI and ACS Style

Root, M.M.; McGinn, M.C.; Nieman, D.C.; Henson, D.A.; Heinz, S.A.; Shanely, R.A.; Knab, A.M.; Jin, F. Combined Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a Cross-Sectional Study in a Community Setting. Nutrients 2012, 4, 29-41.

AMA Style

Root MM, McGinn MC, Nieman DC, Henson DA, Heinz SA, Shanely RA, Knab AM, Jin F. Combined Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a Cross-Sectional Study in a Community Setting. Nutrients. 2012; 4(1):29-41.

Chicago/Turabian Style

Root, Martin M.; McGinn, Megan C.; Nieman, David C.; Henson, Dru A.; Heinz, Serena A.; Shanely, R. Andrew; Knab, Amy M.; Jin, Fuxia. 2012. "Combined Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a Cross-Sectional Study in a Community Setting." Nutrients 4, no. 1: 29-41.

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