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Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?
School of Paediatrics and Child health, University of Western Australia, Perth, Western Australia 6008, Australia
* Author to whom correspondence should be addressed.
Received: 11 November 2011; in revised form: 2 December 2011 / Accepted: 20 December 2011 / Published: 28 December 2011
Abstract: A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1α,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases.
Keywords: vitamin D; 25(OH)D; helper T cells; allergy; vitamin D receptor; immune system
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Jones, A.P.; Tulic, M.K.; Rueter, K.; Prescott, S.L. Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel? Nutrients 2012, 4, 13-28.
Jones AP, Tulic MK, Rueter K, Prescott SL. Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel? Nutrients. 2012; 4(1):13-28.
Jones, Anderson P.; Tulic, Meri K.; Rueter, Kristina; Prescott, Susan L. 2012. "Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?" Nutrients 4, no. 1: 13-28.