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Nutrients 2012, 4(1), 13-28; doi:10.3390/nu4010013
Review

Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?

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Received: 11 November 2011; in revised form: 2 December 2011 / Accepted: 20 December 2011 / Published: 28 December 2011
(This article belongs to the Special Issue Nutritional Immunology)
View Full-Text   |   Download PDF [198 KB, uploaded 28 December 2011]
Abstract: A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1α,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases.
Keywords: vitamin D; 25(OH)D; helper T cells; allergy; vitamin D receptor; immune system vitamin D; 25(OH)D; helper T cells; allergy; vitamin D receptor; immune system
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jones, A.P.; Tulic, M.K.; Rueter, K.; Prescott, S.L. Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel? Nutrients 2012, 4, 13-28.

AMA Style

Jones AP, Tulic MK, Rueter K, Prescott SL. Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel? Nutrients. 2012; 4(1):13-28.

Chicago/Turabian Style

Jones, Anderson P.; Tulic, Meri K.; Rueter, Kristina; Prescott, Susan L. 2012. "Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?" Nutrients 4, no. 1: 13-28.


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