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Nutrients 2012, 4(1), 13-28; doi:10.3390/nu4010013

Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?

School of Paediatrics and Child health, University of Western Australia, Perth, Western Australia 6008, Australia
Author to whom correspondence should be addressed.
Received: 11 November 2011 / Revised: 2 December 2011 / Accepted: 20 December 2011 / Published: 28 December 2011
(This article belongs to the Special Issue Nutritional Immunology)
View Full-Text   |   Download PDF [198 KB, uploaded 28 December 2011]


A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1α,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases. View Full-Text
Keywords: vitamin D; 25(OH)D; helper T cells; allergy; vitamin D receptor; immune system vitamin D; 25(OH)D; helper T cells; allergy; vitamin D receptor; immune system
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jones, A.P.; Tulic, M.K.; Rueter, K.; Prescott, S.L. Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel? Nutrients 2012, 4, 13-28.

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