Immunological Function of Sphingosine 1-Phosphate in the Intestine
AbstractIt has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
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Kunisawa, J.; Kiyono, H. Immunological Function of Sphingosine 1-Phosphate in the Intestine. Nutrients 2012, 4, 154-166.
Kunisawa J, Kiyono H. Immunological Function of Sphingosine 1-Phosphate in the Intestine. Nutrients. 2012; 4(3):154-166.Chicago/Turabian Style
Kunisawa, Jun; Kiyono, Hiroshi. 2012. "Immunological Function of Sphingosine 1-Phosphate in the Intestine." Nutrients 4, no. 3: 154-166.