Immunological Function of Sphingosine 1-Phosphate in the Intestine
AbstractIt has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism. View Full-Text
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Kunisawa, J.; Kiyono, H. Immunological Function of Sphingosine 1-Phosphate in the Intestine. Nutrients 2012, 4, 154-166.
Kunisawa J, Kiyono H. Immunological Function of Sphingosine 1-Phosphate in the Intestine. Nutrients. 2012; 4(3):154-166.Chicago/Turabian Style
Kunisawa, Jun; Kiyono, Hiroshi. 2012. "Immunological Function of Sphingosine 1-Phosphate in the Intestine." Nutrients 4, no. 3: 154-166.