Next Article in Journal
Folate Production by Probiotic Bacteria
Next Article in Special Issue
Probiotics in Inflammatory Bowel Diseases and Associated Conditions
Previous Article in Journal
Vitamin A Metabolism: An Update
Article Menu

Export Article

Open AccessReview
Nutrients 2011, 3(1), 104-117; doi:10.3390/nu3010104

Effect of Lactobacilli on Paracellular Permeability in the Gut

Division of Applied Nutrition, Department of Food Technology, Engineering and Nutrition, Lund University, P.O. Box 124, SE-22100 Lund, Sweden
Author to whom correspondence should be addressed.
Received: 2 December 2010 / Revised: 28 December 2010 / Accepted: 11 January 2011 / Published: 12 January 2011
(This article belongs to the Special Issue Probiotics and Nutrition)
View Full-Text   |   Download PDF [289 KB, uploaded 12 January 2011]   |  


Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells.
Keywords: intestinal lactobacilli; probiotics; paracellular permeability; tight junctions intestinal lactobacilli; probiotics; paracellular permeability; tight junctions
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ahrne, S.; Johansson Hagslatt, M.-L. Effect of Lactobacilli on Paracellular Permeability in the Gut. Nutrients 2011, 3, 104-117.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top