Nutrients 2011, 3(2), 245-264; doi:10.3390/nu3020245

Probiotics in Inflammatory Bowel Diseases and Associated Conditions

Children’s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
Received: 1 January 2011; in revised form: 17 January 2011 / Accepted: 15 February 2011 / Published: 17 February 2011
(This article belongs to the Special Issue Probiotics and Nutrition)
PDF Full-text Download PDF Full-Text [297 KB, uploaded 17 February 2011 11:31 CET]
Abstract: A complex set of interactions between the human genes encoding innate protective functions and immune defenses and the environment of the intestinal mucosa with its microbiota is currently considered key to the pathogenesis of the chronic inflammatory bowel diseases (IBD). Probiotics offer a method to potentially alter the intestinal microbiome exogenously or may provide an option to deliver microbial metabolic products to alter the chronicity of intestinal mucosal inflammation characterizing IBD. At present, there is little evidence for the benefit of currently used probiotic microbes in Crohn’s disease or associated conditions affecting extra-intestinal organs. However, clinical practice guidelines are now including a probiotic as an option for recurrent and relapsing antibiotic sensitive pouchitis and the use of probiotics in mild ulcerative colitis is provocative and suggests potential for benefit in select patients but concerns remain about proof from trials.
Keywords: Crohn’s disease; ulcerative colitis; pouchitis; spondyloartopathy; arthralgia; sclerosing cholangitis; maintenance; induction; remission

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mack, D.R. Probiotics in Inflammatory Bowel Diseases and Associated Conditions. Nutrients 2011, 3, 245-264.

AMA Style

Mack DR. Probiotics in Inflammatory Bowel Diseases and Associated Conditions. Nutrients. 2011; 3(2):245-264.

Chicago/Turabian Style

Mack, David R. 2011. "Probiotics in Inflammatory Bowel Diseases and Associated Conditions." Nutrients 3, no. 2: 245-264.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert