Nutrients 2010, 2(2), 181-197; doi:10.3390/nu2020181
Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats
Megan R. Ruth 1, Ye Wang 2, Howe-Ming Yu 2, Susan Goruk 2, Martin J. Reaney 3, Spencer D. Proctor 2, Donna F. Vine 2 and Catherine J. Field 2,*
1
Boston University School of Medicine, 72 East Concord Street, Robinson 4400, Boston, MA, 02118, USA
2
Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, T6G 2P5, Canada
3
Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada
*
Author to whom correspondence should be addressed.
Received: 14 December 2009 / Accepted: 8 February 2010 / Published: 11 February 2010
(This article belongs to the Special Issue Phospholipid Nutrition)
Abstract
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL. View Full-TextKeywords:
vaccenic acid; elaidic acid; phospholipid; obese; immune; inflammation; cytokines; trans fat
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ruth, M.R.; Wang, Y.; Yu, H.-M.; Goruk, S.; Reaney, M.J.; Proctor, S.D.; Vine, D.F.; Field, C.J. Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats. Nutrients 2010, 2, 181-197.
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