Nutrients 2010, 2(2), 181-197; doi:10.3390/nu2020181
Article

Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats

1 Boston University School of Medicine, 72 East Concord Street, Robinson 4400, Boston, MA, 02118, USA 2 Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, T6G 2P5, Canada 3 Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada
* Author to whom correspondence should be addressed.
Received: 14 December 2009; Accepted: 8 February 2010 / Published: 11 February 2010
(This article belongs to the Special Issue Phospholipid Nutrition)
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Abstract: This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.
Keywords: vaccenic acid; elaidic acid; phospholipid; obese; immune; inflammation; cytokines; trans fat

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MDPI and ACS Style

Ruth, M.R.; Wang, Y.; Yu, H.-M.; Goruk, S.; Reaney, M.J.; Proctor, S.D.; Vine, D.F.; Field, C.J. Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats. Nutrients 2010, 2, 181-197.

AMA Style

Ruth MR, Wang Y, Yu H-M, Goruk S, Reaney MJ, Proctor SD, Vine DF, Field CJ. Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats. Nutrients. 2010; 2(2):181-197.

Chicago/Turabian Style

Ruth, Megan R.; Wang, Ye; Yu, Howe-Ming; Goruk, Susan; Reaney, Martin J.; Proctor, Spencer D.; Vine, Donna F.; Field, Catherine J. 2010. "Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats." Nutrients 2, no. 2: 181-197.

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