Nutrients 2010, 2(2), 181-197; doi:10.3390/nu2020181
Article

Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats

Received: 14 December 2009; Accepted: 8 February 2010 / Published: 11 February 2010
(This article belongs to the Special Issue Phospholipid Nutrition)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.
Keywords: vaccenic acid; elaidic acid; phospholipid; obese; immune; inflammation; cytokines; trans fat
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MDPI and ACS Style

Ruth, M.R.; Wang, Y.; Yu, H.-M.; Goruk, S.; Reaney, M.J.; Proctor, S.D.; Vine, D.F.; Field, C.J. Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats. Nutrients 2010, 2, 181-197.

AMA Style

Ruth MR, Wang Y, Yu H-M, Goruk S, Reaney MJ, Proctor SD, Vine DF, Field CJ. Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats. Nutrients. 2010; 2(2):181-197.

Chicago/Turabian Style

Ruth, Megan R.; Wang, Ye; Yu, Howe-Ming; Goruk, Susan; Reaney, Martin J.; Proctor, Spencer D.; Vine, Donna F.; Field, Catherine J. 2010. "Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats." Nutrients 2, no. 2: 181-197.

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