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Nutrients 2010, 2(11), 1141-1155; doi:10.3390/nu2111141
Article

The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis

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Received: 11 October 2010; in revised form: 11 November 2010 / Accepted: 19 November 2010 / Published: 23 November 2010
(This article belongs to the Special Issue Dairy Nutrients)
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Abstract: The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using 1H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum l-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.
Keywords: metabonomics; 1H-NMR spectroscopy; Irritable Bowel Syndrome; acidified milk products; multivariate data analysis; lactate; probiotics metabonomics; 1H-NMR spectroscopy; Irritable Bowel Syndrome; acidified milk products; multivariate data analysis; lactate; probiotics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pedersen, S.M.M.; Nielsen, N.C.; Andersen, H.J.; Olsson, J.; Simrén, M.; Öhman, L.; Svensson, U.; Malmendal, A.; Bertram, H.C. The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis. Nutrients 2010, 2, 1141-1155.

AMA Style

Pedersen SMM, Nielsen NC, Andersen HJ, Olsson J, Simrén M, Öhman L, Svensson U, Malmendal A, Bertram HC. The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis. Nutrients. 2010; 2(11):1141-1155.

Chicago/Turabian Style

Pedersen, Simon M. M.; Nielsen, Niels Chr.; Andersen, Henrik J.; Olsson, Johan; Simrén, Magnus; Öhman, Lena; Svensson, Ulla; Malmendal, Anders; Bertram, Hanne C. 2010. "The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis." Nutrients 2, no. 11: 1141-1155.



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