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Nutrients 2010, 2(11), 1141-1155; doi:10.3390/nu2111141
Article

The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis

1,2,†
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1 Department of Food Science, Faculty of Agricultural Sciences, Aarhus University, Blichers Allé 20, P.O. Box 50, DK-8830 Tjele, Denmark 2 Center for Insoluble Protein Structures, Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, University of Aarhus, Langelandsgade 140, DK-8000 Aarhus C, Denmark 3 Arla Foods amba, P.O. Box 2400, DK-8260 Viby J, Denmark 4 KPL Good Food Practice AB, Dag Hammarskjölds vag 10 B 3tr, 751 83 Uppsala, Sweden 5 Department of Internal Medicine, Bruna Stråket 11, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden Current address: Aarhus University Hospital, Department of Ophthalmology, Norrebrogade 44, 8000 Aarhus C, Denmark.
* Author to whom correspondence should be addressed.
Received: 11 October 2010 / Revised: 11 November 2010 / Accepted: 19 November 2010 / Published: 23 November 2010
(This article belongs to the Special Issue Dairy Nutrients)
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Abstract

The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using 1H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum l-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.
Keywords: metabonomics; 1H-NMR spectroscopy; Irritable Bowel Syndrome; acidified milk products; multivariate data analysis; lactate; probiotics metabonomics; 1H-NMR spectroscopy; Irritable Bowel Syndrome; acidified milk products; multivariate data analysis; lactate; probiotics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pedersen, S.M.M.; Nielsen, N.C.; Andersen, H.J.; Olsson, J.; Simrén, M.; Öhman, L.; Svensson, U.; Malmendal, A.; Bertram, H.C. The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis. Nutrients 2010, 2, 1141-1155.

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