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Nutrients 2018, 10(2), 185; doi:10.3390/nu10020185

Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis

1
School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing 400016, China
2
Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing 400016, China
3
College of Stomatology, Chongqing Medical University, Chongqing 401147, China
4
Chongqing key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China
*
Author to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 19 January 2018 / Accepted: 26 January 2018 / Published: 8 February 2018
(This article belongs to the Special Issue Dietary Cholesterol:Is It Related to Chronic Disease)
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Abstract

Multiple epidemiologic studies have evaluated the relationship between dietary cholesterol and lung cancer risk, but the association is controversial and inconclusive. A meta-analysis of case-control studies and cohort studies was conducted to evaluate the relationship between dietary cholesterol intake and lung cancer risk in this study. A relevant literature search up to October 2017 was performed in Web of Science, PubMed, China National Knowledge Infrastructure, Sinomed, and VIP Journal Integration Platform. Ten case-control studies and six cohort studies were included in the meta-analysis, and the risk estimates were pooled using either fixed or random effects models. The case-control studies with a total of 6894 lung cancer cases and 29,736 controls showed that dietary cholesterol intake was positively associated with lung cancer risk (Odds Ratio = 1.70, 95% Confidence Interval: 1.43–2.03). However, there was no evidence of an association between dietary cholesterol intake and risk of lung cancer among the 241,920 participants and 1769 lung cancer cases in the cohort studies (Relative Risk = 1.08, 95% Confidence Interval: 0.94–1.25). Due to inconsistent results from case-control and cohort studies, it is difficult to draw any conclusion regarding the effects of dietary cholesterol intake on lung cancer risk. Carefully designed and well-conducted cohort studies are needed to identify the association between dietary cholesterol and lung cancer risk. View Full-Text
Keywords: dietary cholesterol; lung cancer; cholesterol metabolism; case-control study; cohort study; meta-analysis dietary cholesterol; lung cancer; cholesterol metabolism; case-control study; cohort study; meta-analysis
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Lin, X.; Liu, L.; Fu, Y.; Gao, J.; He, Y.; Wu, Y.; Lian, X. Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis. Nutrients 2018, 10, 185.

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