Special Issue "Dietary Cholesterol:Is It Related to Chronic Disease"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (30 April 2018)
Dietary cholesterol is a controversial nutrient, which needs to be further discussed. On the one hand, many countries, including the United States, do not have specific recommendations to limit the intake of cholesterol while, on the other hand, dietary cholesterol is used to induce disease states in animal models. These two contradictory statements bring a high level of uncertainty regarding the role of dietary cholesterol in promoting disease. It is important to understand that in the case of animal models, dietary cholesterol is used in pharmacological doses as a means for developing atherosclerosis, increasing systemic inflammation, and promoting non-alcoholic fatty liver disease. In most cases, the extreme doses given to animal models are to study specific metabolic alterations or pathways associated with the disease, and are not used as models of the human response to dietary cholesterol. The scientific community should be able to unequivocally distinguish between the amount of cholesterol provided in the typical human diet, versus the much larger doses of dietary cholesterol used to induce chronic disease in animal models.
This Special Issue will include topics related to the effects of dietary cholesterol on 1) epidemiological studies of dietary cholesterol and human disease, 2) clinical studies examining dietary cholesterol provided by the regular diet (including high cholesterol foods) and disease risk, and 3) the relationship of dietary cholesterol to development of chronic disease in animal models.
Prof. Maria Luz Fernandez
Prof. Christopher Blesso
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Dietary cholesterol
- clinical studies
- plasma lipoproteins
- reverse cholesterol transport
- animal studies
- fatty liver
- oxidative stress