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• Marzban, G
• Laimer, M
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• Laimer, M
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• Marzban, G
• Laimer, M

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Nutrients 2009, 1(2), 119-132; doi:10.3390/nu1020119

Review

Functional Genomics of Allergen Gene Families in Fruits

Fatemeh Maghuly, Gorji Marzban and Margit Laimer*

Plant Biotechnology Unit, IAM, Department of Biotechnology, VIBT BOKU, 1190 Vienna, Austria

* Author to whom correspondence should be addressed.

Received: 7 October 2009 / Accepted: 21 October 2009 / Published: 28 October 2009

(This article belongs to the Special Issue Foodomics 2009)

Download PDF Full-Text [516 KB, uploaded 2 November 2009 10:23 CET]

Abstract: Fruit consumption is encouraged for health reasons; however, fruits may harbour a series of allergenic proteins that may cause discomfort or even represent serious threats to certain individuals. Thus, the identification and characterization of allergens in fruits requires novel approaches involving genomic and proteomic tools. Since avoidance of fruits also negatively affects the quality of patients’ lives, biotechnological interventions are ongoing to produce low allergenic fruits by down regulating specific genes. In this respect, the control of proteins associated with allergenicity could be achieved by fine tuning the spatial and temporal expression of the relevant genes.

Keywords: temperate fruits; small fruits; pathogenesis-related proteins; Southern Blot; RT-PCR; ELISA; Immuno Tissue Printing; Western Blot; 2D-electrophoresis; Agrobacterium mediated transformation; RNAi approach

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