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Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice
Department of Nutrition, The University of Tennessee, Knoxville, TN 37996-1920, USA
* Author to whom correspondence should be addressed.
Received: 9 July 2009; Accepted: 10 August 2009 / Published: 14 August 2009
Abstract: Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.
Keywords: aging; lifespan; oxidative stress; inflammatory stress; dietary calcium; dairy
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Bruckbauer, A.; Zemel, M.B. Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice. Nutrients 2009, 1, 50-70.
Bruckbauer A, Zemel MB. Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice. Nutrients. 2009; 1(1):50-70.
Bruckbauer, Antje; Zemel, Michael B. 2009. "Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice." Nutrients 1, no. 1: 50-70.