Nutrients 2009, 1(2), 178-196; doi:10.3390/nu1020178
Article

Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food Intake and Brown Adipose Tissue in Rats

Received: 15 October 2009; Accepted: 24 November 2009 / Published: 26 November 2009
(This article belongs to the Special Issue Obesity, Nutrition and Dietetics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.
Keywords: conjugated linoleic acid; n-3 long chain polyunsaturated fatty acid; white adipose tissue; brown adipose tissue; hypothalamus; brain
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MDPI and ACS Style

Sneddon, A.A.; Rayner, D.V.; Mitchell, S.E.; Bashir, S.; Ha, J.-H.; Wahle, K.W.; Morris, A.C.; Williams, L.M. Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food Intake and Brown Adipose Tissue in Rats. Nutrients 2009, 1, 178-196.

AMA Style

Sneddon AA, Rayner DV, Mitchell SE, Bashir S, Ha J-H, Wahle KW, Morris AC, Williams LM. Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food Intake and Brown Adipose Tissue in Rats. Nutrients. 2009; 1(2):178-196.

Chicago/Turabian Style

Sneddon, Alan A.; Rayner, D. Vernon; Mitchell, Sharon E.; Bashir, Shabina; Ha, Jung-Heun; Wahle, Klaus W.; Morris, Amanda C.; Williams, Lynda M. 2009. "Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food Intake and Brown Adipose Tissue in Rats." Nutrients 1, no. 2: 178-196.

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