Next Article in Journal
Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection
Next Article in Special Issue
Latency, Integration, and Reactivation of Human Herpesvirus-6
Previous Article in Journal
Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging
Previous Article in Special Issue
Chromosomally Integrated Human Herpesvirus 6: Models of Viral Genome Release from the Telomere and Impacts on Human Health
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Viruses 2017, 9(7), 192; doi:10.3390/v9070192

Drosophila: Retrotransposons Making up Telomeres

Institute of Evolutionary Biology, IBE, CSIC—Pompeu Fabra University, Barcelona Spain, Passeig de la Barceloneta 37-49, 08003 Barcelona, Spain
Received: 9 June 2017 / Revised: 14 July 2017 / Accepted: 17 July 2017 / Published: 19 July 2017
(This article belongs to the Special Issue Viruses and Telomeres)
View Full-Text   |   Download PDF [1353 KB, uploaded 20 July 2017]   |  

Abstract

Drosophila and extant species are the best-studied telomerase exception. In this organism, telomere elongation is coupled with targeted retrotransposition of Healing Transposon (HeT-A) and Telomere Associated Retrotransposon (TART) with sporadic additions of Telomere Associated and HeT-A Related (TAHRE), all three specialized non-Long Terminal Repeat (non-LTR) retrotransposons. These three very special retroelements transpose in head to tail arrays, always in the same orientation at the end of the chromosomes but never in interior locations. Apparently, retrotransposon and telomerase telomeres might seem very different, but a detailed view of their mechanisms reveals similarities explaining how the loss of telomerase in a Drosophila ancestor could successfully have been replaced by the telomere retrotransposons. In this review, we will discover that although HeT-A, TART, and TAHRE are still the only examples to date where their targeted transposition is perfectly tamed into the telomere biology of Drosophila, there are other examples of retrotransposons that manage to successfully integrate inside and at the end of telomeres. Because the aim of this special issue is viral integration at telomeres, understanding the base of the telomerase exceptions will help to obtain clues on similar strategies that mobile elements and viruses could have acquired in order to ensure their survival in the host genome. View Full-Text
Keywords: telomere integration, HeT-A, TART, TAHRE, Drosophila, telomere targeting telomere integration, HeT-A, TART, TAHRE, Drosophila, telomere targeting
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Casacuberta, E. Drosophila: Retrotransposons Making up Telomeres. Viruses 2017, 9, 192.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top