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Viruses 2017, 9(7), 184; doi:10.3390/v9070184

Chromosomally Integrated Human Herpesvirus 6: Models of Viral Genome Release from the Telomere and Impacts on Human Health

Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
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Received: 2 June 2017 / Revised: 30 June 2017 / Accepted: 5 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue Viruses and Telomeres)
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Abstract

Human herpesvirus 6A and 6B, alongside some other herpesviruses, have the striking capacity to integrate into telomeres, the terminal repeated regions of chromosomes. The chromosomally integrated forms, ciHHV-6A and ciHHV-6B, are proposed to be a state of latency and it has been shown that they can both be inherited if integration occurs in the germ line. The first step in full viral reactivation must be the release of the integrated viral genome from the telomere and here we propose various models of this release involving transcription of the viral genome, replication fork collapse, and t-circle mediated release. In this review, we also discuss the relationship between ciHHV-6 and the telomere carrying the insertion, particularly how the presence and subsequent partial or complete release of the ciHHV-6 genome may affect telomere dynamics and the risk of disease. View Full-Text
Keywords: human herpesvirus 6; HHV-6; telomere; viral reactivation; replication; integration human herpesvirus 6; HHV-6; telomere; viral reactivation; replication; integration
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Wood, M.L.; Royle, N.J. Chromosomally Integrated Human Herpesvirus 6: Models of Viral Genome Release from the Telomere and Impacts on Human Health. Viruses 2017, 9, 184.

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