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Viruses 2017, 9(7), 193; doi:10.3390/v9070193

Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection

1
Klinikum rechts der Isar, Technischen Universität München (TUM), Ismaniger Str. 22, 81675 Munich, Germany
2
Institute of Cytology of the Russian Academy of Sciences (RAS), Tikhoretsky Ave., 4, 194064 St. Petersburg, Russia
3
Institute of Virology, Technische Universität München/Helmholtz Zentrum München—German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 4 June 2017 / Revised: 1 July 2017 / Accepted: 6 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Recent Advances in Hepatitis B Virus Research)
View Full-Text   |   Download PDF [870 KB, uploaded 21 July 2017]   |  

Abstract

Chronic infection with the hepatitis B virus (HBV) can lead to liver failure and can cause liver cirrhosis and hepatocellular carcinoma (HCC). Reliable means for detecting and monitoring HBV infection are essential to identify patients in need of therapy and to prevent HBV transmission. Nanomaterials with defined electrical, optical, and mechanical properties have been developed to detect and quantify viral antigens. In this review, we discuss the challenges in applying nanoparticles to HBV antigen detection and in realizing the bio-analytical potential of such nanoparticles. We discuss recent developments in generating detection platforms based on gold and iron oxide nanoparticles. Such platforms increase biological material detection efficiency by the targeted capture and concentration of HBV antigens, but the unique properties of nanoparticles can also be exploited for direct, sensitive, and specific antigen detection. We discuss several studies that show that nanomaterial-based platforms enable ultrasensitive HBV antigen detection. View Full-Text
Keywords: hepatitis B; virus; magnetic nanoparticles; gold nanoparticles; biosensor hepatitis B; virus; magnetic nanoparticles; gold nanoparticles; biosensor
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Shevtsov, M.; Zhao, L.; Protzer, U.; Klundert, M.A.A. Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection. Viruses 2017, 9, 193.

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