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Viruses 2017, 9(10), 287; doi:10.3390/v9100287

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

1
Department of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada
2
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
3
School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 September 2017 / Revised: 28 September 2017 / Accepted: 1 October 2017 / Published: 3 October 2017
(This article belongs to the Special Issue Homage to Mark Wainberg)
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Abstract

Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research. View Full-Text
Keywords: flavivirus; Zika virus; Dengue virus; antiviral; therapy; RNA polymerase flavivirus; Zika virus; Dengue virus; antiviral; therapy; RNA polymerase
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MDPI and ACS Style

Sze, A.; Olagnier, D.; Hadj, S.B.; Han, X.; Tian, X.H.; Xu, H.-T.; Yang, L.; Shi, Q.; Wang, P.; Wainberg, M.A.; Wu, J.H.; Lin, R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses 2017, 9, 287.

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