Next Article in Journal
An Insight into Cotton Leaf Curl Multan Betasatellite, the Most Important Component of Cotton Leaf Curl Disease Complex
Next Article in Special Issue
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
Previous Article in Journal
A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Viruses 2017, 9(10), 281; doi:10.3390/v9100281

Current Peptide and Protein Candidates Challenging HIV Therapy beyond the Vaccine Era

1
Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
2
Center of Biomolecular Therapy and Diagnostic, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
3
Institute of Research in Infectious Diseases, CNRS UMR9004, University of Montpellier, 34293 Montpellier, France
4
Division of Clinical Immunology and Transfusion Sciences, School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand
5
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand
*
Authors to whom correspondence should be addressed.
Received: 12 August 2017 / Revised: 27 September 2017 / Accepted: 28 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Homage to Mark Wainberg)
View Full-Text   |   Download PDF [636 KB, uploaded 30 September 2017]   |  

Abstract

Human immunodeficiency virus (HIV) is a causative agent of acquired immune deficiency syndrome (AIDS). Highly active antiretroviral therapy (HAART) can slow down the replication of HIV-1, leading to an improvement in the survival of HIV-1-infected patients. However, drug toxicities and poor drug administration has led to the emergence of a drug-resistant strain. HIV-1 immunotherapy has been continuously developed, but antibody therapy and HIV vaccines take time to improve its efficiency and have limitations. HIV-1-specific chimeric antigen receptor (CAR)-based immunotherapy founded on neutralizing antibodies is now being developed. In HIV-1 therapy, anti-HIV chimeric antigen receptors showed promising data in the suppression of HIV-1 replication; however, autologous transfusion is still a problem. This has led to the development of effective peptides and proteins for an alternative HIV-1 treatment. In this paper, we provide a comprehensive review of potent anti-HIV-1 peptides and proteins that reveal promising therapeutic activities. The inhibitory mechanisms of each therapeutic molecule in the different stages of the HIV-1 life cycle will be discussed herein. View Full-Text
Keywords: HIV; HIV gene therapy; HIV vaccine; assembly inhibitor; entry inhibitor; fusion inhibitor; integration inhibitor HIV; HIV gene therapy; HIV vaccine; assembly inhibitor; entry inhibitor; fusion inhibitor; integration inhibitor
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chupradit, K.; Moonmuang, S.; Nangola, S.; Kitidee, K.; Yasamut, U.; Mougel, M.; Tayapiwatana, C. Current Peptide and Protein Candidates Challenging HIV Therapy beyond the Vaccine Era. Viruses 2017, 9, 281.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top