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Viruses 2017, 9(10), 288; doi:10.3390/v9100288

Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Received: 18 September 2017 / Revised: 1 October 2017 / Accepted: 3 October 2017 / Published: 4 October 2017
(This article belongs to the Special Issue Viruses and Autophagy)
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Abstract

Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies. View Full-Text
Keywords: Epstein Barr virus; Varizella Zoster virus; poliovirus; coxsackie B virus; MHC class I molecules; MHC class II molecules; LAP (LC3 associated phagocytosis) Epstein Barr virus; Varizella Zoster virus; poliovirus; coxsackie B virus; MHC class I molecules; MHC class II molecules; LAP (LC3 associated phagocytosis)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Münz, C. Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses. Viruses 2017, 9, 288.

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