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Viruses 2017, 9(10), 283; doi:10.3390/v9100283

Assessing Monkeypox Virus Prevalence in Small Mammals at the Human–Animal Interface in the Democratic Republic of the Congo

1
U.S. Centers for Disease Control and Prevention, Poxvirus and Rabies Branch, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA
2
University of Kinshasa, Department of Biology, P.O. Box 218 Kinshasa XI, Democratic Republic of the Congo
3
Field Museum of Natural History, 1400 S. Lake Shore Dr., Chicago, IL 60605, USA
4
Biodiversity Institute, University of Kansas, 1345 Jayhawk Blvd., Lawrence, KS 66045, USA
5
University of Wisconsin, School of Veterinary Medicine, 2015 Linden Dr., Madison, WI 53706, USA
6
U.S. Geological Survey, National Wildlife Health Center, 6006 Schroeder Rd., Madison, WI 53711, USA
*
Author to whom correspondence should be addressed.
Received: 7 August 2017 / Revised: 15 September 2017 / Accepted: 19 September 2017 / Published: 3 October 2017
(This article belongs to the Special Issue Smallpox and Emerging Zoonotic Orthopoxviruses: What Is Coming Next?)
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Abstract

During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were previously confirmed near these collection sites. Samples were collected from 353 mammals (rodents, shrews, pangolins, elephant shrews, a potamogale, and a hyrax). Some rodents and shrews were captured from houses where human monkeypox cases have recently been identified, but most were trapped in forests and agricultural areas near villages. Real-time PCR and ELISA were used to assess evidence of MPXV infection and other Orthopoxvirus (OPXV) infections in these small mammals. Seven (2.0%) of these animal samples were found to be anti-orthopoxvirus immunoglobulin G (IgG) antibody positive (six rodents: two Funisciurus spp.; one Graphiurus lorraineus; one Cricetomys emini; one Heliosciurus sp.; one Oenomys hypoxanthus, and one elephant shrew Petrodromus tetradactylus); no individuals were found positive in PCR-based assays. These results suggest that a variety of animals can be infected with OPXVs, and that epidemiology studies and educational campaigns should focus on animals that people are regularly contacting, including larger rodents used as protein sources. View Full-Text
Keywords: habitat analysis; human–animal interface; monkeypox; orthopoxviruses; serology; small mammals; wildlife habitat analysis; human–animal interface; monkeypox; orthopoxviruses; serology; small mammals; wildlife
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MDPI and ACS Style

Doty, J.B.; Malekani, J.M.; Kalemba, L.N.; Stanley, W.T.; Monroe, B.P.; Nakazawa, Y.U.; Mauldin, M.R.; Bakambana, T.L.; Liyandja Dja Liyandja, T.; Braden, Z.H.; Wallace, R.M.; Malekani, D.V.; McCollum, A.M.; Gallardo-Romero, N.; Kondas, A.; Peterson, A.T.; Osorio, J.E.; Rocke, T.E.; Karem, K.L.; Emerson, G.L.; Carroll, D.S. Assessing Monkeypox Virus Prevalence in Small Mammals at the Human–Animal Interface in the Democratic Republic of the Congo. Viruses 2017, 9, 283.

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