Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway
AbstractThe mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs. View Full-Text
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Le Sage, V.; Cinti, A.; Amorim, R.; Mouland, A.J. Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway. Viruses 2016, 8, 152.
Le Sage V, Cinti A, Amorim R, Mouland AJ. Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway. Viruses. 2016; 8(6):152.Chicago/Turabian Style
Le Sage, Valerie; Cinti, Alessandro; Amorim, Raquel; Mouland, Andrew J. 2016. "Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway." Viruses 8, no. 6: 152.