Next Article in Journal
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly
Next Article in Special Issue
Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses
Previous Article in Journal
Phylogenetic and Molecular Variability Studies Reveal a New Genetic Clade of Citrus leprosis virus C
Previous Article in Special Issue
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway
Article Menu

Export Article

Open AccessReview
Viruses 2016, 8(6), 162; doi:10.3390/v8060162

Stress Response and Translation Control in Rotavirus Infection

Departamento de Génetica del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Received: 7 April 2016 / Revised: 26 May 2016 / Accepted: 31 May 2016 / Published: 7 June 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
View Full-Text   |   Download PDF [2556 KB, uploaded 7 June 2016]   |  

Abstract

The general stress and innate immune responses are closely linked and overlap at many levels. The outcomes of these responses serve to reprogram host expression patterns to prevent viral invasions. In turn, viruses counter attack these cell responses to ensure their replication. The mechanisms by which viruses attempt to control host cell responses are as varied as the number of different virus families. One of the most recurrent strategies used by viruses to control the antiviral response of the cell is to hijack the translation machinery of the host, such that viral proteins are preferentially synthesized, while the expression of the stress and antiviral responses of the cell are blocked at the translation level. Here, we will review how rotaviruses, an important agent of acute severe gastroenteritis in children, overcome the stress responses of the cell to establish a productive infectious cycle. View Full-Text
Keywords: rotavirus; antiviral response; stress response; unfolded protein response; protein synthesis; RNA granules; stress granules; processing bodies rotavirus; antiviral response; stress response; unfolded protein response; protein synthesis; RNA granules; stress granules; processing bodies
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

López, S.; Oceguera, A.; Sandoval-Jaime, C. Stress Response and Translation Control in Rotavirus Infection. Viruses 2016, 8, 162.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top