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Viruses 2016, 8(4), 97; doi:10.3390/v8040097

Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation

Department of Microbiology & Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
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Academic Editor: Craig McCormick
Received: 1 March 2016 / Revised: 25 March 2016 / Accepted: 31 March 2016 / Published: 13 April 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
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Abstract

mRNA translation requires the ordered assembly of translation initiation factors and ribosomal subunits on a transcript. Host signaling pathways regulate each step in this process to match levels of protein synthesis to environmental cues. In response to infection, cells activate multiple defenses that limit viral protein synthesis, which viruses must counteract to successfully replicate. Human cytomegalovirus (HCMV) inhibits host defenses that limit viral protein expression and manipulates host signaling pathways to promote the expression of both host and viral proteins necessary for virus replication. Here we review key regulatory steps in mRNA translation, and the strategies used by HCMV to maintain protein synthesis in infected cells. View Full-Text
Keywords: human cytomegalovirus; HCMV; protein synthesis; mRNA translation; translation initiation; eIF4F complex; mTOR signaling; eIF2α human cytomegalovirus; HCMV; protein synthesis; mRNA translation; translation initiation; eIF4F complex; mTOR signaling; eIF2α
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Vincent, H.A.; Ziehr, B.; Moorman, N.J. Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation. Viruses 2016, 8, 97.

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