Next Article in Journal
Next-Generation Sequencing in the Understanding of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Biology
Next Article in Special Issue
Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation
Previous Article in Journal
Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques
Previous Article in Special Issue
Alphaherpesvirus Subversion of Stress-Induced Translational Arrest
Article Menu

Export Article

Open AccessReview
Viruses 2016, 8(4), 93; doi:10.3390/v8040093

Enterovirus Control of Translation and RNA Granule Stress Responses

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Academic Editor: Craig McCormick
Received: 29 February 2016 / Revised: 26 March 2016 / Accepted: 29 March 2016 / Published: 30 March 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
View Full-Text   |   Download PDF [964 KB, uploaded 30 March 2016]   |  

Abstract

Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) have evolved several parallel strategies to regulate cellular gene expression and stress responses to ensure efficient expression of the viral genome. Enteroviruses utilize their encoded proteinases to take over the cellular translation apparatus and direct ribosomes to viral mRNAs. In addition, viral proteinases are used to control and repress the two main types of cytoplasmic RNA granules, stress granules (SGs) and processing bodies (P-bodies, PBs), which are stress-responsive dynamic structures involved in repression of gene expression. This review discusses these processes and the current understanding of the underlying mechanisms with respect to enterovirus infections. In addition, the review discusses accumulating data suggesting linkage exists between RNA granule formation and innate immune sensing and activation. View Full-Text
Keywords: enterovirus; poliovirus; coxsackievirus; translation shutoff; stress granules; P-bodies enterovirus; poliovirus; coxsackievirus; translation shutoff; stress granules; P-bodies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lloyd, R.E. Enterovirus Control of Translation and RNA Granule Stress Responses. Viruses 2016, 8, 93.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top