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Viruses 2013, 5(7), 1850-1866; doi:10.3390/v5071850
Review

Structural and Functional Insights into Foamy Viral Integrase

,
 and
*
Department of Biotechnology, Chung-Ang University, Ansung 456-756, South Korea
* Author to whom correspondence should be addressed.
Received: 24 June 2013 / Revised: 12 July 2013 / Accepted: 12 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Recent Progress in Foamy Virus (FV) Research)
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Abstract

Successful integration of retroviral DNA into the host chromosome is an essential step for viral replication. The process is mediated by virally encoded integrase (IN) and orchestrated by 3'-end processing and the strand transfer reaction. In vitro reaction conditions, such as substrate specificity, cofactor usage, and cellular binding partners for such reactions by the three distinct domains of prototype foamy viral integrase (PFV-IN) have been described well in several reports. Recent studies on the three‑dimensional structure of the interacting complexes between PFV-IN and DNA, cofactors, binding partners, or inhibitors have explored the mechanistic details of such interactions and shown its utilization as an important target to develop anti-retroviral drugs. The presence of a potent, non-transferable nuclear localization signal in the PFV C-terminal domain extends its use as a model for investigating cellular trafficking of large molecular complexes through the nuclear pore complex and also to identify novel cellular targets for such trafficking. This review focuses on recent advancements in the structural analysis and in vitro functional aspects of PFV-IN.
Keywords: foamy virus; integrase; anti-retroviral drugs; cellular trafficking foamy virus; integrase; anti-retroviral drugs; cellular trafficking
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hossain, M.A.; Ali, M.K.; Shin, C.-G. Structural and Functional Insights into Foamy Viral Integrase. Viruses 2013, 5, 1850-1866.

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