Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
Abstract
:1. Introduction
1.1. Human Papillomaviruses
1.2. Polycomb Group Proteins and Homeobox Genes
2. Dysregulation of Homeobox Gene Expression in Cervical Cancers
3. Association of HPV16 E7 with Polycomb Group Proteins
3.1. HPV16 E7
3.2. Association of HPV16 E7 with E2F6 Containing Polycomb Repressive Complexes
3.3. Decreased Trimethylation of Lysine 27 of Histone H3 in HPV16 E7 Expressing Cells
4. Modulation of Polycomb Group Protein Expression by HPV16 Oncoproteins
4.1. Increased EZH2 Expression in HPV E7 Expressing Cells
4.2. Modulation of BMI1 Expression by HPV E6 and E7
5. Modulation of PRC Regulators by HPV16 E7
5.1. Upregulation of the H3K27 Demethylases KDM6A and KDM6B
5.2. KDM6B Controls Epithelial Differentiation
5.3. KDM6B Mediates the Oncogene-Induced Senescence (OIS) Response to RAS/RAF
5.4. HPV16 E7 Induces the Cervical Cancer Biomarker p16INK4A through KDM6B
5.5. Dysregulated Homeobox Gene Expression in HPV16 E7 Expressing Cells
5.6. KDM6A and KDM6B are Essential in Cervical Carcinoma Cells
6. Concluding Remarks
Acknowledgments
Conflict of Interest
References
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McLaughlin-Drubin, M.E.; Munger, K. Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins. Viruses 2013, 5, 1231-1249. https://doi.org/10.3390/v5051231
McLaughlin-Drubin ME, Munger K. Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins. Viruses. 2013; 5(5):1231-1249. https://doi.org/10.3390/v5051231
Chicago/Turabian StyleMcLaughlin-Drubin, Margaret E., and Karl Munger. 2013. "Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins" Viruses 5, no. 5: 1231-1249. https://doi.org/10.3390/v5051231