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An addendum was published on 11 July 2013, see Viruses 2013, 5(7), 1682-1683.

Viruses 2013, 5(5), 1219-1230; doi:10.3390/v5051219
Article

Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus

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Received: 30 March 2013; in revised form: 22 April 2013 / Accepted: 22 April 2013 / Published: 29 April 2013
(This article belongs to the Section Antivirals & Vaccines)
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Abstract: The Hepatitis C virus causes chronic infections in humans, which can develop to liver cirrhosis and hepatocellular carcinoma. The Bovine viral diarrhea virus is used as a surrogate model for antiviral assays for the HCV. From marine invertebrates and microorganisms isolated from them, extracts were prepared for assessment of their possible antiviral activity. Of the 128 tested, 2 were considered active and 1 was considered promising. The best result was obtained from the extracts produced from the Bacillus sp. isolated from the sponge Petromica citrina. The extracts 555 (500 µg/mL, SI>18) and 584 (150 µg/mL, SI 27) showed a percentage of protection of 98% against BVDV, and the extract 616, 90% of protection. All of them showed activity during the viral adsorption. Thus, various substances are active on these studied organisms and may lead to the development of drugs which ensure an alternative therapy for the treatment of hepatitis C.
Keywords: hepatitis C virus; antiviral agents; marine microorganisms hepatitis C virus; antiviral agents; marine microorganisms
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bastos, J.C.S.; Kohn, L.K.; Fantinatti-Garboggini, F.; Padilla, M.A.; Flores, E.F.; da Silva, B.P.; de Menezes, C.B.A.; Arns, C.W. Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus. Viruses 2013, 5, 1219-1230.

AMA Style

Bastos JCS, Kohn LK, Fantinatti-Garboggini F, Padilla MA, Flores EF, da Silva BP, de Menezes CBA, Arns CW. Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus. Viruses. 2013; 5(5):1219-1230.

Chicago/Turabian Style

Bastos, Juliana C.S.; Kohn, Luciana K.; Fantinatti-Garboggini, Fabiana; Padilla, Marina A.; Flores, Eduardo F.; da Silva, Bárbara P.; de Menezes, Cláudia B.A.; Arns, Clarice W. 2013. "Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus." Viruses 5, no. 5: 1219-1230.


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