Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Viruses 2013, 5(2), 595-604; doi:10.3390/v5020595
Review

HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition

*  and
Received: 12 December 2012; in revised form: 24 January 2013 / Accepted: 31 January 2013 / Published: 6 February 2013
(This article belongs to the Special Issue Viral Entry Inhibitors)
Download PDF [568 KB, uploaded 6 February 2013]
Abstract: Entry of HIV-1 into a host cell is a multi-step process, with the viral envelope gp120 and gp41 acting sequentially to mediate the viral attachment, CD4 binding, coreceptor binding, and fusion of the viral and host membranes. The emerging class of antiretroviral agents, collectively known as entry inhibitors, interfere in some of these steps. However, viral diversity has implications for possible differential responses to entry inhibitors, since envelope is the most variable of all HIV genes. Different HIV genetic forms carry in their genomes genetic signatures and polymorphisms that could alter the structure of viral proteins which are targeted by drugs, thus impairing antiretroviral binding and efficacy. This review will examine current research that describes subtype differences in envelope at the genetic level and the effects of mutations on the efficacy of current entry inhibitors.
Keywords: HIV-1; entry inhibitors; envelope; diversity HIV-1; entry inhibitors; envelope; diversity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Araújo, L.A.L.; Almeida, S.E.M. HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition. Viruses 2013, 5, 595-604.

AMA Style

Araújo LAL, Almeida SEM. HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition. Viruses. 2013; 5(2):595-604.

Chicago/Turabian Style

Araújo, Leonardo A.L.; Almeida, Sabrina E.M. 2013. "HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition." Viruses 5, no. 2: 595-604.



Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert