Viruses 2013, 5(2), 577-594; doi:10.3390/v5020577

Respiratory Syncytial Virus: Current Progress in Vaccine Development

1 Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA 2 Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
* Author to whom correspondence should be addressed.
Received: 16 January 2013; in revised form: 1 February 2013 / Accepted: 4 February 2013 / Published: 5 February 2013
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
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Abstract: Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infection risks are inversely associated with neutralizing antibody titers suggest that immune responses generated toward a first RSV exposure can significantly reduce morbidity and mortality throughout life. For more than half a century, researchers have endeavored to design a vaccine for RSV that can mimic or improve upon natural protective immunity without adverse events. The virus is herein described together with the hurdles that must be overcome to develop a vaccine and some current vaccine development approaches.
Keywords: respiratory syncytial virus; candidate vaccines; protective immunity

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MDPI and ACS Style

Rudraraju, R.; Jones, B.G.; Sealy, R.; Surman, S.L.; Hurwitz, J.L. Respiratory Syncytial Virus: Current Progress in Vaccine Development. Viruses 2013, 5, 577-594.

AMA Style

Rudraraju R, Jones BG, Sealy R, Surman SL, Hurwitz JL. Respiratory Syncytial Virus: Current Progress in Vaccine Development. Viruses. 2013; 5(2):577-594.

Chicago/Turabian Style

Rudraraju, Rajeev; Jones, Bart G.; Sealy, Robert; Surman, Sherri L.; Hurwitz, Julia L. 2013. "Respiratory Syncytial Virus: Current Progress in Vaccine Development." Viruses 5, no. 2: 577-594.

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