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Human Cytomegalovirus Manipulation of Latently Infected Cells
Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK
Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
* Author to whom correspondence should be addressed.
Received: 17 October 2013; in revised form: 11 November 2013 / Accepted: 13 November 2013 / Published: 21 November 2013
Abstract: Primary infection with human cytomegalovirus (HCMV) results in the establishment of a lifelong infection of the host which is aided by the ability of HCMV to undergo a latent infection. One site of HCMV latency in vivo is in haematopoietic progenitor cells, resident in the bone marrow, with genome carriage and reactivation being restricted to the cells of the myeloid lineage. Until recently, HCMV latency has been considered to be relatively quiescent with the virus being maintained essentially as a “silent partner” until conditions are met that trigger reactivation. However, advances in techniques to study global changes in gene expression have begun to show that HCMV latency is a highly active process which involves expression of specific latency-associated viral gene products which orchestrate major changes in the latently infected cell. These changes are argued to help maintain latent infection and to modulate the cellular environment to the benefit of latent virus. In this review, we will discuss these new findings and how they impact not only on our understanding of the biology of HCMV latency but also how they could provide tantalising glimpses into mechanisms that could become targets for the clearance of latent HCMV.
Keywords: cytomegalovirus; latency; immune evasion; apoptosis; gene expression; cellular signalling
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MDPI and ACS Style
Sinclair, J.H.; Reeves, M.B. Human Cytomegalovirus Manipulation of Latently Infected Cells. Viruses 2013, 5, 2803-2824.
Sinclair JH, Reeves MB. Human Cytomegalovirus Manipulation of Latently Infected Cells. Viruses. 2013; 5(11):2803-2824.
Sinclair, John H.; Reeves, Matthew B. 2013. "Human Cytomegalovirus Manipulation of Latently Infected Cells." Viruses 5, no. 11: 2803-2824.