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Viruses 2013, 5(11), 2796-2802; doi:10.3390/v5112796
Letter

Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain

1,* , 1, 2, 1 and 1
Received: 13 August 2013; in revised form: 10 October 2013 / Accepted: 8 November 2013 / Published: 19 November 2013
(This article belongs to the Section Antivirals & Vaccines)
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Abstract: The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal influenza viruses. It has changed the pre-existing immunity of the human population to succeeding infections. In the present study, a total of 14,210 distinct sequences downloaded from National Center for Biotechnology Information (NCBI) database were used for the analysis. The epitope compositions in A (H1N1)pdm09, classic seasonal strains, swine strains as well as highly virulent avian strain H5N1, identified with the aid of the Immune Epitope DataBase (IEDB), were compared at genomic level. The result showed that A (H1N1) pdm09 contains the 90% of B-cell epitopes for broadly cross-reactive antibodies (EBCA), which is in consonance with the recent reports on the experimental identification of new epitopes or antibodies for this virus and the binding tests with influenza virus protein HA of different subtypes. Our analysis supports that high proportional EBCA depends on the epitope pattern of A (H1N1)pdm09 virus. This study may be helpful for better understanding of A (H1N1)pdm09 and the production of new influenza vaccines.
Keywords: influenza A virus; H1N1; pandemic; epitopes; genome comparison influenza A virus; H1N1; pandemic; epitopes; genome comparison
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lara-Ramírez, E.E.; Segura-Cabrera, A.; Salazar, M.I.; Rodríguez-Pérez, M.A.; Guo, X. Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain. Viruses 2013, 5, 2796-2802.

AMA Style

Lara-Ramírez EE, Segura-Cabrera A, Salazar MI, Rodríguez-Pérez MA, Guo X. Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain. Viruses. 2013; 5(11):2796-2802.

Chicago/Turabian Style

Lara-Ramírez, Edgar E.; Segura-Cabrera, Aldo; Salazar, Ma I.; Rodríguez-Pérez, Mario A.; Guo, Xianwu. 2013. "Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain." Viruses 5, no. 11: 2796-2802.


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