Next Article in Journal
Roles of microRNAs in the Hepatitis B Virus Infection and Related Diseases
Next Article in Special Issue
Poxviruses in Bats … so What?
Previous Article in Journal
Involvement of Eukaryotic Small RNA Pathways in Host Defense and Viral Pathogenesis
Viruses 2013, 5(11), 2679-2689; doi:10.3390/v5112679
Brief Report

Detection of Coronaviruses in Bats of Various Species in Italy

1,†,* , 1,†
1 Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Via Bianchi 9, Brescia 25124, Italy 2 IZO s.r.l, Via S. Zeno 99/A, Brescia 25124, Italy 3 Centro Fauna Selvatica "Il Pettirosso", Via Nonantolana 1217, Modena 41122, Italy These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 27 September 2013 / Revised: 25 October 2013 / Accepted: 28 October 2013 / Published: 31 October 2013
(This article belongs to the Special Issue Viruses and Bats)
View Full-Text   |   Download PDF [336 KB, uploaded 12 May 2015]   |   Browse Figure


Bats are natural reservoirs for many mammalian coronaviruses, which have received renewed interest after the discovery of the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) CoV in humans. This study describes the identification and molecular characterization of alphacoronaviruses and betacoronaviruses in bats in Italy, from 2010 to 2012. Sixty-nine faecal samples and 126 carcasses were tested using pan-coronavirus RT-PCR. Coronavirus RNAs were detected in seven faecal samples and nine carcasses. A phylogenetic analysis of RNA-dependent RNA polymerase sequence fragments aided in identifying two alphacoronaviruses from Kuhl’s pipistrelle (Pipistrellus kuhlii), three clade 2b betacoronaviruses from lesser horseshoe bats (Rhinolophus hipposideros), and 10 clade 2c betacoronaviruses from Kuhl’s pipistrelle, common noctule (Nyctalus noctula), and Savi’s pipistrelle (Hypsugo savii). This study fills a substantive gap in the knowledge on bat-CoV ecology in Italy, and extends the current knowledge on clade 2c betacoronaviruses with new sequences obtained from bats that have not been previously described as hosts of these viruses.
Keywords: coronavirus; bats; Italy; molecular characterization; phylogenetic analysis coronavirus; bats; Italy; molecular characterization; phylogenetic analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Lelli, D.; Papetti, A.; Sabelli, C.; Rosti, E.; Moreno, A.; Boniotti, M.B. Detection of Coronaviruses in Bats of Various Species in Italy. Viruses 2013, 5, 2679-2689.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert