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Viruses 2013, 5(1), 340-351; doi:10.3390/v5010340
Review

Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers

1,* , 1
, 1
 and 2
Received: 22 December 2012; in revised form: 17 January 2013 / Accepted: 18 January 2013 / Published: 21 January 2013
(This article belongs to the Special Issue Arenaviruses)
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Abstract: Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
Keywords: hemostasis; endothelium; platelets; megakaryocytes; coagulation; thrombocytopenia; interferon; nitric oxide hemostasis; endothelium; platelets; megakaryocytes; coagulation; thrombocytopenia; interferon; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Schattner, M.; Rivadeneyra, L.; Pozner, R.G.; Gómez, R.M. Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers. Viruses 2013, 5, 340-351.

AMA Style

Schattner M, Rivadeneyra L, Pozner RG, Gómez RM. Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers. Viruses. 2013; 5(1):340-351.

Chicago/Turabian Style

Schattner, Mirta; Rivadeneyra, Leonardo; Pozner, Roberto G.; Gómez, Ricardo M. 2013. "Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers." Viruses 5, no. 1: 340-351.


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