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Viruses 2013, 5(1), 340-351; doi:10.3390/v5010340
Review

Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers

1,* , 1
, 1
 and 2
1 Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET, National Academy of Medicine. Pacheco de Melo 3081 (1425), Buenos Aires, Argentina 2 Laboratory of Animal Virus, Institute of Biotechnology and Molecular Biology, CONICET-UNLP, Calle 49 esq 115 (1900), La Plata, Argentina
* Author to whom correspondence should be addressed.
Received: 22 December 2012 / Revised: 17 January 2013 / Accepted: 18 January 2013 / Published: 21 January 2013
(This article belongs to the Special Issue Arenaviruses)
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Abstract

Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
Keywords: hemostasis; endothelium; platelets; megakaryocytes; coagulation; thrombocytopenia; interferon; nitric oxide hemostasis; endothelium; platelets; megakaryocytes; coagulation; thrombocytopenia; interferon; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schattner, M.; Rivadeneyra, L.; Pozner, R.G.; Gómez, R.M. Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers. Viruses 2013, 5, 340-351.

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