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Host Cell Factors as Antiviral Targets in Arenavirus Infection
Viruses 2012, 4(9), 1802-1829; doi:10.3390/v4091802

Animal Models, Prophylaxis, and Therapeutics for Arenavirus Infections

1 Battelle, 505 King Ave, Columbus, OH 43201, USA 2 Center for Predictive Medicine, University of Louisville, 950 N. Hurstbourne Parkway, Louisville, KY 40222, USA
Received: 3 August 2012 / Revised: 19 September 2012 / Accepted: 21 September 2012 / Published: 24 September 2012
(This article belongs to the Special Issue Arenaviruses)
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Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans, limited treatment options, and potential as a bio-weapon, the development of prophylactics and therapeutics is essential. This article reviews the current arenavirus animal models and prophylactic and therapeutic strategies under development to treat arenavirus infection.
Keywords: arenavirus; prophylaxis; therapeutics; hemorrhagic fever; animal models arenavirus; prophylaxis; therapeutics; hemorrhagic fever; animal models
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vela, E. Animal Models, Prophylaxis, and Therapeutics for Arenavirus Infections. Viruses 2012, 4, 1802-1829.

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